MyBioSource.com's TXNRD1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The TXNRD1 Antibody was generated using thioredoxin reductase 1, and TXNRD1 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Function: Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Subunit Structure: Homodimer. Isoform 4 interacts with ESR1 and ESR2. Interacts with HERC5.
Post-translational Modifications: The N-terminus of isoform 5 is blocked. ISGylated.
Similarity: The N-terminal glutaredoxin domain found in isoform 1 does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family